Product Name :
GSK2795039
Description:
GSK2795039 is a NADPH oxidase 2 (NOX2) inhibitor with a mean pIC50 of 6 in different cell-free assays. GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 reduces apoptosis.
CAS:
1415925-18-6
Molecular Weight:
450.56
Formula:
C23H26N6O2S
Chemical Name:
1-methyl-N-[3-(1-methyl-2, 3-dihydro-1H-indol-6-yl)-1-(propan-2-yl)-1H-pyrrolo[2, 3-b]pyridin-4-yl]-1H-pyrazole-3-sulfonamide
Smiles :
CN1CCC2=CC=C(C=C12)C1=CN(C(C)C)C2=NC=CC(NS(=O)(=O)C3C=CN(C)N=3)=C12
InChiKey:
FMWVTCZKCXPKFW-UHFFFAOYSA-N
InChi :
InChI=1S/C23H26N6O2S/c1-15(2)29-14-18(17-6-5-16-8-11-27(3)20(16)13-17)22-19(7-10-24-23(22)29)26-32(30,31)21-9-12-28(4)25-21/h5-7,9-10,12-15H,8,11H2,1-4H3,(H,24,26)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
GSK2795039 is a NADPH oxidase 2 (NOX2) inhibitor with a mean pIC50 of 6 in different cell-free assays. GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 reduces apoptosis.|Product information|CAS Number: 1415925-18-6|Molecular Weight: 450.56|Formula: C23H26N6O2S|Chemical Name: 1-methyl-N-[3-(1-methyl-2, 3-dihydro-1H-indol-6-yl)-1-(propan-2-yl)-1H-pyrrolo[2, 3-b]pyridin-4-yl]-1H-pyrazole-3-sulfonamide|Smiles: CN1CCC2=CC=C(C=C12)C1=CN(C(C)C)C2=NC=CC(NS(=O)(=O)C3C=CN(C)N=3)=C12|InChiKey: FMWVTCZKCXPKFW-UHFFFAOYSA-N|InChi: InChI=1S/C23H26N6O2S/c1-15(2)29-14-18(17-6-5-16-8-11-27(3)20(16)13-17)22-19(7-10-24-23(22)29)26-32(30,31)21-9-12-28(4)25-21/h5-7,9-10,12-15H,8,11H2,1-4H3,(H,24,26)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 32 mg/mL (71.{{Anamorelin} medchemexpress|{Anamorelin} GHSR|{Anamorelin} Purity & Documentation|{Anamorelin} Description|{Anamorelin} supplier|{Anamorelin} Autophagy} 02 mM)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Ajmaline} web|{Ajmaline} Sodium Channel|{Ajmaline} Purity & Documentation|{Ajmaline} In Vivo|{Ajmaline} supplier|{Ajmaline} Autophagy} |Shelf Life: ≥360 days if stored properly.PMID:32644709 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|GSK2795039 (25 μM; 24 hours) reduces the combinatory effect of FeSO4 and LPS-increased levels of apoptosis and reduced the presence of caspase-3-positive PC12 cells.|In Vivo:|GSK2795039 (intraperitoneal injection; 100 mg/kg; 1 hour before) decreases activity in a murine model of acute pancreatitis, reducing the levels of serum amylase triggered by systemic injection of cerulein.|References:|Hirano K, et al. Discovery of GSK2795039, a Novel Small Molecule NADPH Oxidase 2 Inhibitor. Antioxid Redox Signal. 2015 Aug 10;23(5):358-74.Yauger YJ, et al. Iron accentuated reactive oxygen species release by NADPH oxidase in activated microglia contributes to oxidative stress in vitro. J Neuroinflammation. 2019 Feb 18;16(1):41.Products are for research use only. Not for human use.|