0 = 6.73, OLDER logEC50 = 2.66.Table 2. Top 20 genes ranked by real fold decrease in uterine horn from 8-week-old laboring rats (YOUNG) compared to 24-week-old laboring rats jasp.12117 (OLDER). Fold decrease ?0.0 ?.8 ?.9 ?.9 ?.8 ?.3 ?.2 ?.9 ?.8 ?.8 ?.7 ?.7 ?.3 ?.3 ?.1 ?.0 ?.9 ?.9 ?.8 ?.7 ?.6 Entrez gene ID 24177 54225 287774 * 292668 24856 55939 315907 25105 309122 691157 24483 25065 292697 363493 171045 171528 29366 140914 50669 65029 Unigene ID Rn.9174 Rn.33815 Rn.1824 * Rn.Pleconaril site 205326 Rn.1404 Rn.262 Rn.214057 Rn.3835 Rn.6171 Rn.182598 Rn.118681 Rn.14799 Rn.16843 Rn.46187 Rn.32086 Rn.21395 Rn.2271 Rn.87449 Rn.11206 Rn.54493 Gene symbol Afp Apob Apoh Prl Ceacam11 Ttr Apom Nrk Nppb H19 Pramef12 Igf2 Slc12a1 Apoc2 Taf7 l Mmp3 Gzmb Serpine2 Olr1 Prf1 Aoc1 Entrez gene name Alpha-fetoprotein Apolipoprotein B (including Ag(x) antigen) Apolipoprotein H (beta-2-glycoprotein I) Prolactin family 2?, subfamily, and members Carcinoembryonic antigen-related cell adhesion molecule 11 Transthyretin Apolipoprotein M Nik-related kinase Natriuretic peptide type B H19, imprinted maternally expressed transcript (nonprotein coding) PRAME family member 12 Insulin-like growth factor 2 (somatomedin A) Solute carrier family 12 (sodium/potassium/chloride transporters), member 1 Apolipoprotein C-II TAF7-like RNA polymerase II, TATA-box-binding protein (TBP)-associated factor, 50 kDa Matrix metallopeptidase 3 (stromelysin 1, progelatinase) Granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) Serpin peptidase inhibitor, clade E (nexin, AZD0156 supplement plasminogen activator inhibitor type 1), member 2 Oxidized-low-density lipoprotein (lectin-like) receptor 1 Perforin 1 (pore-forming protein) Amiloride-binding protein 1 (amine oxidase (copper-containing))All P < 0.05. *Represented by >1 probe on the SART.S23506 array; and include significant fold increases in 10 genes including Prl2a1, 2c1, 4a1, 5a1, 5a2, 6a1, 7a3, 7b1, 7d1, and 8a5.?2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.2015 | Vol. 3 | Iss. 4 | e12305 PageAging Effects on Uterine ContractilityM. Elmes et al.Table 3. Top 20 genes ranked by real fold increase in uterine horn from 8-week-old laboring rats (YOUNG) compared to 24-week-old laboring rats (OLDER). Fold increase 5.1 3.0 2.6 2.2 2.2 2.2 2.1 2.1 2.0 2.0 1.9 1.9 1.9 1.9 1.8 1.8 1.8 1.8 1.8 1.8 All P < 0.05. Entrez gene ID 25575 116831 81658 304081 24795 60665 289546 25424 407762 295176 311793 81779 311803 289949 29527 65162 25098 619558 688684 368066 Unigene ID Rn.2206 Rn.3896 Rn.21401 Rn.214050 Rn.202939 Rn.44449 Rn.136778 Rn.92738 Rn.154794 Rn.178258 Rn.162651 Rn.32256 Rn.154622 Rn.38497 Rn.44369 Rn.88380 Rn.10470 Rn.162560 Rn.198280 Rn.19133 Gene symbol Scgb1a1 Fxdy3 Gabrp Clic6 Serpina3n Cxcl6 Tmprss11 g Ctse Krt85 Cd79a Noxa1 Sctr Lrrc26 Fam3d Ptgs2 Dio2 Foxa1 Fam134b LOC688684 Inmt Entrez gene name Secretoglobin, family 1A, member 1 (uteroglobin) FXYD domain containing ion transport regulator 3 Gamma-aminobutyric acid (GABA) A receptor, pi Chloride intracellular channel 6 Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 Chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) Transmembrane protease, serine 11 g Cathepsin E Keratin 85 Cd79a molecule, immunoglobulin-associated alpha NADPH oxidase activator 1 Secretin receptor Leucine-rich repeat containing 26 Family with sequence similarity 3, member D Prostaglandi.0 = 6.73, OLDER logEC50 = 2.66.Table 2. Top 20 genes ranked by real fold decrease in uterine horn from 8-week-old laboring rats (YOUNG) compared to 24-week-old laboring rats jasp.12117 (OLDER). Fold decrease ?0.0 ?.8 ?.9 ?.9 ?.8 ?.3 ?.2 ?.9 ?.8 ?.8 ?.7 ?.7 ?.3 ?.3 ?.1 ?.0 ?.9 ?.9 ?.8 ?.7 ?.6 Entrez gene ID 24177 54225 287774 * 292668 24856 55939 315907 25105 309122 691157 24483 25065 292697 363493 171045 171528 29366 140914 50669 65029 Unigene ID Rn.9174 Rn.33815 Rn.1824 * Rn.205326 Rn.1404 Rn.262 Rn.214057 Rn.3835 Rn.6171 Rn.182598 Rn.118681 Rn.14799 Rn.16843 Rn.46187 Rn.32086 Rn.21395 Rn.2271 Rn.87449 Rn.11206 Rn.54493 Gene symbol Afp Apob Apoh Prl Ceacam11 Ttr Apom Nrk Nppb H19 Pramef12 Igf2 Slc12a1 Apoc2 Taf7 l Mmp3 Gzmb Serpine2 Olr1 Prf1 Aoc1 Entrez gene name Alpha-fetoprotein Apolipoprotein B (including Ag(x) antigen) Apolipoprotein H (beta-2-glycoprotein I) Prolactin family 2?, subfamily, and members Carcinoembryonic antigen-related cell adhesion molecule 11 Transthyretin Apolipoprotein M Nik-related kinase Natriuretic peptide type B H19, imprinted maternally expressed transcript (nonprotein coding) PRAME family member 12 Insulin-like growth factor 2 (somatomedin A) Solute carrier family 12 (sodium/potassium/chloride transporters), member 1 Apolipoprotein C-II TAF7-like RNA polymerase II, TATA-box-binding protein (TBP)-associated factor, 50 kDa Matrix metallopeptidase 3 (stromelysin 1, progelatinase) Granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 Oxidized-low-density lipoprotein (lectin-like) receptor 1 Perforin 1 (pore-forming protein) Amiloride-binding protein 1 (amine oxidase (copper-containing))All P < 0.05. *Represented by >1 probe on the SART.S23506 array; and include significant fold increases in 10 genes including Prl2a1, 2c1, 4a1, 5a1, 5a2, 6a1, 7a3, 7b1, 7d1, and 8a5.?2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.2015 | Vol. 3 | Iss. 4 | e12305 PageAging Effects on Uterine ContractilityM. Elmes et al.Table 3. Top 20 genes ranked by real fold increase in uterine horn from 8-week-old laboring rats (YOUNG) compared to 24-week-old laboring rats (OLDER). Fold increase 5.1 3.0 2.6 2.2 2.2 2.2 2.1 2.1 2.0 2.0 1.9 1.9 1.9 1.9 1.8 1.8 1.8 1.8 1.8 1.8 All P < 0.05. Entrez gene ID 25575 116831 81658 304081 24795 60665 289546 25424 407762 295176 311793 81779 311803 289949 29527 65162 25098 619558 688684 368066 Unigene ID Rn.2206 Rn.3896 Rn.21401 Rn.214050 Rn.202939 Rn.44449 Rn.136778 Rn.92738 Rn.154794 Rn.178258 Rn.162651 Rn.32256 Rn.154622 Rn.38497 Rn.44369 Rn.88380 Rn.10470 Rn.162560 Rn.198280 Rn.19133 Gene symbol Scgb1a1 Fxdy3 Gabrp Clic6 Serpina3n Cxcl6 Tmprss11 g Ctse Krt85 Cd79a Noxa1 Sctr Lrrc26 Fam3d Ptgs2 Dio2 Foxa1 Fam134b LOC688684 Inmt Entrez gene name Secretoglobin, family 1A, member 1 (uteroglobin) FXYD domain containing ion transport regulator 3 Gamma-aminobutyric acid (GABA) A receptor, pi Chloride intracellular channel 6 Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 Chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) Transmembrane protease, serine 11 g Cathepsin E Keratin 85 Cd79a molecule, immunoglobulin-associated alpha NADPH oxidase activator 1 Secretin receptor Leucine-rich repeat containing 26 Family with sequence similarity 3, member D Prostaglandi.