regimens and larger sample sizes are necessary. Tumor-based assays require well-preserved biopsy material, are technically difficult, incur substantial costs, and have a slow turnaround time. By contrast, the MALDI-TOF-MS method…
use of anti-angiogenic agents, such as the anti-vascular endothelial growth factor antibody Bevacizumab for breast and other cancers, and small molecule tyrosine kinase inhibitors such as Sunitinib. The absence of…
nd sequenced using Sanger sequencing. Transfection of cells with siRNAs or ASOs For RNAi-guided screening, Huh-luc/neo-ET cells were reverse-transfected with siRNAs using Lipofectamine RNAiMAX reagent. Luc activity was measured 48…
l for immunoprecipitation, an unrelated antibody against EGFP was used. For the control of immunoblotting, an antibody against actin was used. Confocal fluorescence micrographs showing endogenous ULK2 and Kap2 in…
ern of Gi1/2 in the cytoplasm and the localization of LGN were not influenced by the Ric8 siRNA treatment of oocytes. Although the downregulation of Ric8 expression had no statistically…
a sorted list. In contrast to the hierarchical algorithms that have the quadratic asymptotic running time with respect to the number of objects, k-means produces a number of partitions for…
course of a relative PLM phosphorylation level is shown by a solid line. An increase in the phosphorylation level of PLM decreases the Na+ half-saturation constant for the current and…
n -6 demonstrated to be critical for p65-driven gene expression of many target genes. The IKK complex is known to phosphorylate p65 at serine 536, in this way regulating p65…
be used as an indicator of desensitization of b1-ARs. Experimental data on AC activity as a function of isoproterenol were obtained by Freedman et al. at three time moments after…
on of the Jak/STAT pathway has been previously detected after exposure to high-density neutron irradiation. The Wnt pathway has been activated by X-rays and dioxin. Despite previous work demonstrating alterations…