Product Name :
AMG-333
Description:
AMG-333 is a potent and highly selective antagonist of TRPM8 with IC50 values of 13 nM and 30 nM for human TRPM8 and rat TRPM8.
CAS:
1416799-28-4
Molecular Weight:
453.32
Formula:
C20H12F5N3O4
Chemical Name:
6-([3-fluoro-4-(trifluoromethoxy)phenyl](3-fluoropyridin-2-yl)methylcarbamoyl)pyridine-3-carboxylic acid
Smiles :
OC(=O)C1=CN=C(C=C1)C(=O)NC(C1N=CC=CC=1F)C1=CC(F)=C(C=C1)OC(F)(F)F
InChiKey:
QEBYISWYMFIXOZ-UHFFFAOYSA-N
InChi :
InChI=1S/C20H12F5N3O4/c21-12-2-1-7-26-17(12)16(10-4-6-15(13(22)8-10)32-20(23,24)25)28-18(29)14-5-3-11(9-27-14)19(30)31/h1-9,16H,(H,28,29)(H,30,31)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Theophylline Technical Information
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
AMG-333 is a potent and highly selective antagonist of TRPM8 with IC50 values of 13 nM and 30 nM for human TRPM8 and rat TRPM8.|Product information|CAS Number: 1416799-28-4|Molecular Weight: 453.32|Formula: C20H12F5N3O4|Chemical Name: 6-([3-fluoro-4-(trifluoromethoxy)phenyl](3-fluoropyridin-2-yl)methylcarbamoyl)pyridine-3-carboxylic acid|Smiles: OC(=O)C1=CN=C(C=C1)C(=O)NC(C1N=CC=CC=1F)C1=CC(F)=C(C=C1)OC(F)(F)F|InChiKey: QEBYISWYMFIXOZ-UHFFFAOYSA-N|InChi: InChI=1S/C20H12F5N3O4/c21-12-2-1-7-26-17(12)16(10-4-6-15(13(22)8-10)32-20(23,24)25)28-18(29)14-5-3-11(9-27-14)19(30)31/h1-9,16H,(H,28,29)(H,30,31)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Solubility (25°C).Trilostane Protocol 91 mg/mL(200.PMID:33009857 74 mM). Insoluble.|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|