The three important subtypes. These cancers are characterized by diverse genetic perturbations even though they may be similarly triggered by a lifelong exposure for the sun. The main oncogenic drivers of skin cancer initiation have already been identified to get a even though, yet it remains unclear what are the molecular events that mediate their oncogenic functions and that contribute to their progression. Furthermore, patients with aggressive skin cancers happen to be known to develop resistance to at the moment available remedy, which can be urging us to determine new Fesoterodine Purity & Documentation therapeutic opportunities determined by a far better understanding of skin cancer biology. More recently, the contribution of cytoskeletal dynamics and Rho GTPase signaling networks towards the progression of skin cancers has been highlighted by a number of research. Within this critique, we underline the numerous perturbations in the activity and regulation of Rho GTPase network elements that contribute to skin cancer improvement, and we discover the emerging therapeutic opportunities which can be surfacing from these studies. Key phrases: Rho GTPase; RhoGEF; RhoGAP; skin; cancer; squamous cell carcinoma; basal cell carcinoma; melanomaCitation: Pecora, A.; Laprise, J.; Dahmene, M.; Laurin, M. Skin Cancers as well as the Contribution of Rho GTPase Signaling Networks to Their Progression. Cancers 2021, 13, 4362. https://doi.org/10.3390/ cancers13174362 Academic Editor: Paulo Matos Received: 23 July 2021 Accepted: 26 August 2021 Published: 28 AugustPublisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.1. Introduction Skin cancers will be the most typical cancers worldwide, and their incidence continues to rise [1]. The cumulative lifetime exposure to the sun is the main risk factor for establishing skin cancer. Consequently, the worldwide raise in the aging demographic combined together with the improvement of skin cancer detection contribute to their escalating price [2,3]. As a group, skin cancers are largely divided into cutaneous melanoma and nonmelanoma skin cancers. Basal cell carcinoma of the skin (BCC) and cutaneous squamous cell carcinoma (cSCC) are the most frequent types of nonmelanoma skin cancers [4]. In reality, BCC is definitely the most typical cancer in humans, yet cSCC incidence is on the rise [5,6]. Melanoma, BCC and cSCC diverge with regards to their aggressiveness, cell of origin and mutational landscape [1]. Over the years, corresponding therapeutic strategies for their remedy haveCopyright: 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and situations on the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ four.0/).Cancers 2021, 13, 4362. https://doi.org/10.3390/cancershttps://www.mdpi.com/journal/cancersCancers 2021, 13,sistant situations. Due to their capacity to regulate cytoskeletal remodeling, Rho GTPases hav viewed as key regulators of tumor invasion [7,8]. But, these networks also orch of 18 ious cellular functions which include gene expression, cell proliferation 2and cell su when perturbed, contribute to cancer progression [8,9]. In reality, the aberrant ex Rho GTPases, the presence of mutations that modify their activity as well as emerged. Nevertheless, enhancing our comprehension from the biology of melanoma, BCC their regulation have been Thiacloprid Cell Cycle/DNA Damage observed for the duration of cancer progression [8,9]. For the and cSCC remains essential to enhance our capacity to effectively determine lesions together with the Rho GTP.