Gnificant.Author Contributions: Conceptualization, J.M.K.; methodology, J.I.J.; software, J.I.J.; validation, J.I.J. and J.M.K.; formal evaluation, J.I.J., K.H.L. and J.M.K.; investigation, J.M.K.; sources, J.M.K. and K.H.L.; data curation, J.I.J., and J.M.K.; writing–original draft preparation, J.M.K.; writing–review and editing, J.M.K.; visualization, J.I.J.; supervision, J.M.K.; project administration, J.M.K.; funding acquisition, J.M.K. and K.H.L. All authors have study and agreed for the published version with the manuscript. Funding: This research was supported by the fundamental Science Study Program via the National Study Foundation of Korea (NRF) funded by the IHR-1 supplier Ministry of Education, Science and Technology (MEST) (NRF-2021R1F1A1045550), Republic of Korea. Institutional Assessment Board Statement: Not applicable. Informed Consent Statement: Not applicable. Conflicts of Interest: The authors have no conflict of interest to declare.International Journal ofMolecular SciencesReviewIntermolecular Diels-Alder Cycloadditions of Coumarin-SAHA Data Sheet Furfural-Based Chemical compounds from Renewable Sources: A Focus on the Regio- and Diastereoselectivity within the Reaction with AlkenesKonstantin I. Galkin 1,two and Valentine P. Ananikov 1, Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospekt 47, 119991 Moscow, Russia; [email protected] Laboratory of Functional Composite Supplies, Bauman Moscow State Technical University, 2nd Baumanskaya Street 5/1, 105005 Moscow, Russia Correspondence: [email protected]: Galkin, K.I.; Ananikov, V.P. Intermolecular Diels-Alder Cycloadditions of Furfural-Based Chemicals from Renewable Resources: A Focus on the Regio- and Diastereoselectivity within the Reaction with Alkenes. Int. J. Mol. Sci. 2021, 22, 11856. ten.3390/ ijms222111856 Academic Editor: Vladim K en r Received: 14 October 2021 Accepted: 29 October 2021 Published: 1 NovemberAbstract: A current strong trend toward green and sustainable chemistry has promoted the intensive use of renewable carbon sources for the production of polymers, biofuels, chemicals, monomers and other valuable products. The Diels-Alder reaction is of terrific value inside the chemistry of renewable resources and delivers an atom-economic pathway for fine chemical synthesis and for the production of components. The biobased furans furfural and 5-(hydroxymethyl)furfural, which can be easily obtained from the carbohydrate a part of plant biomass, had been recognized as “platform chemicals” that will support to replace the existing oil-based refining to biorefining. Diels-Alder cycloaddition of furanic dienes with numerous dienophiles represents the excellent example of a “green” process characterized by a 100 atom economy along with a reasonable E-factor. In this review, we initially summarize the literature information on the regio- and diastereoselectivity of intermolecular Diels-Alder reactions of furfural derivatives with alkenes with all the aim of establishing the existing progress in the effective production of practically significant low-molecular-weight solutions. The details provided here are going to be helpful and relevant to scientists in numerous fields, which includes medical and pharmaceutical analysis, polymer improvement and supplies science. Keyword phrases: biobased furans; renewable constructing blocks; plant biomass; Diels-Alder cycloaddition; selectivity; sustainable chemistry; biorefining1. Introduction To date, the development of effective technologies for catalytic or biocatalytic conversion of renewable plant biomass into.