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OPENCitation: Cell Death and Disease (2013) 4, e743; doi:10.1038/cddis.2013.268 2013 Macmillan Publishers Restricted All rights reserved 2041-4889/nature.com/cddisDifferentiation of adipose-derived stem cells into Schwann cell phenotype induces expression of P2X receptors that handle cell deathA Faroni*,1,2, SW Rothwell2, AA Grolla2, G Terenghi1, V Magnaghi3 plus a VerkhratskySchwann cells (SCs) are fundamental for improvement, myelination and regeneration in the peripheral nervous program. Slow development rate and difficulties in harvesting limit SC applications in regenerative medicine. Several molecules, which includes receptors for neurosteroids and neurotransmitters, happen to be recommended to nNOS Formulation become implicated in regulating physiology and regenerative prospective of SCs. Adipose-derived stem cells (ASCs) could be differentiated into SC-like phenotype (dASC) sharing morphological and functional properties with SC, therefore representing a valid SC alternative. We have previously shown that dASC express c-aminobutyric-acid receptors, which modulate their proliferation and neurotrophic possible, even though small is recognized regarding the function of other neurotransmitters in ASC. In this study, we investigated the ex.