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(1) Academic Department of Surgery, Cardiovascular Division, King’s ADAM8 manufacturer College London, BHF Centre of Excellence as well as the Biomedical Analysis Centre at Guy’s St Thomas’ NHS Foundation Trust and King’s College London, UK (two) Angiogenesis and Tumor Targeting Unit, and HSR-TIGET, San Raffaele Scientific Institute, Milan, Italy (3) Vita-Salute University, Milan, Italy (4) Swiss Institute for Experimental Cancer Investigation (ISREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland (5) Immunopathogenesis of Liver Infections Unit, San Raffaele Scientific Institute, Milan, Italy (6) Vascular Biology Group, Cardiovascular Division, King’s College London, UK (7) Membrane/Cytoskeletal Signalling Group, Cardiovascular Division, King’s College London, UK (eight) School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, UK *Corresponding author: Tel: four 207 1880216; Fax: 4 207 9288742; E-mail: [email protected] authors contributed equally to this operate.Peripheral arterial occlusive illness (PAOD) affects 1 in 5 people over the age of 75 (Berger and Hiatt, 2012). The spectrum of PAOD ranges from intermittent claudication to essential limb ischemia (CLI). The.