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Major depressive disorder (MDD) may be the most common psychiatric disorder, having a lifetime prevalence of 16.2 as well as a 12-month prevalence of six.6 in developed nations (Trivedi et al, 2007). It represents probably the most critical challenges faced by health-care providers and is a leading reason for disability (Globe Health Organization (WHO), 2009).ENA-78/CXCL5 Protein medchemexpress MDD is characterized by the presence of a single or more significant depressive episodes (MDEs), presenting with depressed mood, loss of interest or pleasure, disturbed sleep or appetite, low power, and feelings of guilt or low self-worth (Uher et al, 2014).ADAM12 Protein Gene ID Mood disorders are also related with impairments in cognitive functioning.PMID:23381626 A increasing physique of evidence from*Correspondence: Dr RSE Keefe, Division of Psychiatry and Behavioral Science, Duke University Healthcare Center, Box 3270 Health-related Center, Durham, NC 27710, USA, Tel: +1 919 684 4306, Fax: +1 919 684 2632, E-mail: [email protected] Received 20 November 2014; revised 26 January 2015; accepted ten February 2015; accepted article preview on the internet 17 Februaryneuropsychological research suggests that lots of sufferers suffering from MDD present with some type of dysfunction in specific cognitive domains, for example executive function, functioning memory, visuospatial short-term memory, immediate an.