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Serum or cerebrospinal fluid (CSF) biomarkers of brain injury happen to be recommended as possible diagnostic adjuncts in neurocritical care since the groundbreaking perform in the laboratory of Per Vaagenes (Kjekshus et al., 1980; Vaagenes et al., 1980, 1984, 1986, 1987, 1988; Bohmer et al., 1983; Vaagenes, 1986) in experimental and clinical cardiac arrest (CA), anoxic brain injury, stroke, and open heart surgery over 30 years ago. Earlier function in the 1960s concluded th.