Product Name :
Angoline hydrochloride
Description:
Angoline hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline hydrochloride inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation.
CAS:
1071676-04-4
Molecular Weight:
415.87
Formula:
C22H22ClNO5
Chemical Name:
17, 18, 20-trimethoxy-21-methyl-5, 7-dioxa-21-azapentacyclo[11.8.0.0, .0, .0, ]henicosa-1(13), 2, 4(8), 9, 11, 14(19), 15, 17-octaene hydrochloride
Smiles :
Cl.CN1C(OC)C2=C(OC)C(=CC=C2C2=CC=C3C=C4OCOC4=CC3=C12)OC
InChiKey:
IHTYZEWKBYYBBI-UHFFFAOYSA-N
InChi :
InChI=1S/C22H21NO5.ClH/c1-23-20-14(6-5-12-9-17-18(10-15(12)20)28-11-27-17)13-7-8-16(24-2)21(25-3)19(13)22(23)26-4;/h5-10,22H,11H2,1-4H3;1H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Angoline hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline hydrochloride inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation.{{Auranofin} site|{Auranofin} SARS-CoV|{Auranofin} Protocol|{Auranofin} Formula|{Auranofin} manufacturer|{Auranofin} Epigenetic Reader Domain} |Product information|CAS Number: 1071676-04-4|Molecular Weight: 415.{{Oxytocin} MedChemExpress|{Oxytocin} GPCR/G Protein|{Oxytocin} Technical Information|{Oxytocin} In Vivo|{Oxytocin} supplier|{Oxytocin} Cancer} 87|Formula: C22H22ClNO5|Chemical Name: 17, 18, 20-trimethoxy-21-methyl-5, 7-dioxa-21-azapentacyclo[11.PMID:33103586 8.0.0, .0, .0, ]henicosa-1(13), 2, 4(8), 9, 11, 14(19), 15, 17-octaene hydrochloride|Smiles: Cl.CN1C(OC)C2=C(OC)C(=CC=C2C2=CC=C3C=C4OCOC4=CC3=C12)OC|InChiKey: IHTYZEWKBYYBBI-UHFFFAOYSA-N|InChi: InChI=1S/C22H21NO5.ClH/c1-23-20-14(6-5-12-9-17-18(10-15(12)20)28-11-27-17)13-7-8-16(24-2)21(25-3)19(13)22(23)26-4;/h5-10,22H,11H2,1-4H3;1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Jiawei Liu, et al. Angoline: a selective IL-6/STAT3 signaling pathway inhibitor isolated from Zanthoxylum nitidum. Phytomedicine. Jul-Aug 2014;21(8-9):1088-91.Products are for research use only. Not for human use.|