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OPENCitation: Cell Death and Disease (2013) 4, e743; doi:ten.1038/cddis.2013.268 2013 Macmillan Publishers Limited All rights reserved 2041-4889/nature.com/cddisDifferentiation of adipose-derived stem cells into Schwann cell phenotype induces expression of P2X receptors that manage cell deathA Faroni*,1,2, SW Rothwell2, AA Grolla2, G Terenghi1, V Magnaghi3 along with a VerkhratskySchwann cells (SCs) are fundamental for improvement, myelination and regeneration in the peripheral nervous program. Slow growth rate and troubles in harvesting limit SC applications in regenerative medicine. Various molecules, such as receptors for neurosteroids and neurotransmitters, happen to be suggested to be implicated in regulating physiology and regenerative possible of SCs. Adipose-derived stem cells (ASCs) is often differentiated into SC-like phenotype (dASC) sharing morphological and functional properties with SC, therefore representing a valid SC XIAP Accession alternative. We have previously shown that dASC express c-aminobutyric-acid receptors, which modulate their proliferation and neurotrophic potential, even though small is identified in regards to the role of other neurotransmitters in ASC. Within this study, we investigated the ex.