3,3′,4,4′-Benzophenonetetracarboxylic dianhydride, 97+%

Product Name : 3,3',4,4'-Benzophenonetetracarboxylic dianhydride, 97+%Synonym: IUPAC Name : 5-(1,3-dioxo-1,3-dihydro-2-benzofuran-5-carbonyl)-1,3-dihydro-2-benzofuran-1,3-dioneCAS NO.:2421-28-5Molecular Weight : Molecular formula: C17H6O7Smiles: O=C(C1=CC=C2C(=O)OC(=O)C2=C1)C1=CC=C2C(=O)OC(=O)C2=C1Description: BTDA polymer fine free-flowing powder suitable for general purposes.Vincristine sulfate BTDA Microfine Micronized…

N-Ethylmaleimide, 98+%

Product Name : N-Ethylmaleimide, 98+%Synonym: IUPAC Name : 1-ethyl-2,5-dihydro-1H-pyrrole-2,5-dioneCAS NO.:128-53-0Molecular Weight : Molecular formula: C6H7NO2Smiles: CCN1C(=O)C=CC1=ODescription: Cysteine alkylating agent N-Ethylmaleimide is a protein thiol modifier which inhibits apoptotic DNA fragmentation.Balovaptan…

Amoxicillin trihydrate

Product Name : Amoxicillin trihydrateSynonym: IUPAC Name : (2S,5R,6R)-6--3,3-dimethyl-7-oxo-4-thia-1-azabicycloheptane-2-carboxylic acid trihydrateCAS NO.:61336-70-7Molecular Weight : Molecular formula: C16H25N3O8SSmiles: O.O.O.CC1(C)S2(NC(=O)(N)C3=CC=C(O)C=C3)C(=O)N21C(O)=ODescription: Amoxicillin trihydratesemi-synthetic antibiotic related to Penicillin which has antibacterial poperties.Vemurafenib It is…

Bis(2-methylallyl)(1,5-cyclooctadiene)ruthenium(II)

Product Name : Bis(2-methylallyl)(1,5-cyclooctadiene)ruthenium(II)Synonym: IUPAC Name : Bis(2-methylallyl)(1,5-cyclooctadiene)ruthenium(II)CAS NO.:12289-94-0Molecular Weight : 319.Revefenacin 45Molecular formula: C16H26RuSmiles: .Tabalumab Cc(:c):c.PMID:25046520 Cc(:c):c.C1C\C=C/CC\C=C/1Description: Bis(2-methylallyl)(1,5-cyclooctadiene)ruthenium(II) is used as a catalyst and pharmaceutical intermediate. It is also…

beta-Nicotinamide adenine dinucleotide phosphate monosodium salt

Product Name : beta-Nicotinamide adenine dinucleotide phosphate monosodium saltSynonym: IUPAC Name : sodium 1-methyl phosphonato}oxy)(oxido)phosphoryl]oxy}methyl)-3,4-dihydroxyoxolan-2-yl]-3-carbamoyl-1λ⁵-pyridin-1-yliumCAS NO.:1184-16-3Molecular Weight : Molecular formula: C21H27N7NaO17P3Smiles: .NC(=O)C1=CC=C(=C1)1O(COP()(=O)OP()(=O)OC2O((OP(O)(O)=O)2O)N2C=NC3=C(N)N=CN=C23)(O)1ODescription: β-Nicotinamide adenine dinucleotide phosphate monosodium salt acts as…

Glybenzcyclamide, 99%

Product Name : Glybenzcyclamide, 99%Synonym: IUPAC Name : 5-chloro-N-sulfonyl}phenyl)ethyl]-2-methoxybenzamideCAS NO.Datopotamab deruxtecan :10238-21-8Molecular Weight : Molecular formula: C23H28ClN3O5SSmiles: COC1=CC=C(Cl)C=C1C(=O)NCCC1=CC=C(C=C1)S(=O)(=O)NC(=O)NC1CCCCC1Description: Glyburide (Glibenclamide) is a sulfonylurea compound that modulates insulin production.Fludrocortisone acetate Sulfonylureas…

4-Iodo-m-xylene, 98%

Product Name : 4-Iodo-m-xylene, 98%Synonym: IUPAC Name : 1-iodo-2,4-dimethylbenzeneCAS NO.:4214-28-2Molecular Weight : Molecular formula: C8H9ISmiles: CC1=CC=C(I)C(C)=C1Description: 4-Iodo-m-xylene is a reactant used in the preparation of paralog-selective Hsp90 inhibitors.Diosmin Atacicept PMID:33679749

Urease

Product Name : UreaseSynonym: IUPAC Name : CAS NO.4,15-Isoatriplicolide methylacrylate :9002-13-5Molecular Weight : Molecular formula: Smiles: Description: Resibufogenin PMID:25818744 MedChemExpress (MCE) offers a wide range of high-quality research chemicals and…

Hydroxypropyl methyl cellulose, M.N. 86,000; viscosity 4,000mPas (2% solution)

Product Name : Hydroxypropyl methyl cellulose, M.N. 86,000; viscosity 4,000mPas (2% solution)Synonym: IUPAC Name : 1-{oxan-3-yl]oxy}oxan-2-yl]methoxy}propan-2-ol; 3,4,5-trimethoxy-2-(methoxymethyl)-6-{oxy}oxaneCAS NO.Enoblituzumab :9004-65-3Molecular Weight : Molecular formula: C56H108O30Smiles: COCC1OC(OC2C(COC)OC(OC)C(OC)C2OC)C(OC)C(OC)C1OC.Clazosentan CC(O)COCC1OC(OC2C(COCC(C)O)OC(OCC(C)O)C(OCC(C)O)C2OCC(C)O)C(OCC(C)O)C(OCC(C)O)C1OCC(C)ODescription: PMID:35850484

Ramipril, 98%

Product Name : Ramipril, 98%Synonym: IUPAC Name : (2S,3aS,6aS)-1-amino}propanoyl]-octahydrocyclopentapyrrole-2-carboxylic acidCAS NO.:87333-19-5Molecular Weight : Molecular formula: C23H32N2O5Smiles: CCOC(=O)(CCC1=CC=CC=C1)N(C)C(=O)N12CCC2C1C(O)=ODescription: BMS-986278 Hydrocortisone PMID:23805407

(+/-)-2,2′-Bis(di-p-tolylphosphino)-1,1′-binaphthyl, 98%

Product Name : (+/-)-2,2'-Bis(di-p-tolylphosphino)-1,1'-binaphthyl, 98%Synonym: IUPAC Name : {2'---2-yl}bis(4-methylphenyl)phosphaneCAS NO.:153305-67-0Molecular Weight : Molecular formula: C48H40P2Smiles: CC1=CC=C(C=C1)P(C1=CC=C(C)C=C1)C1=CC=C2C=CC=CC2=C1C1=C2C=CC=CC2=CC=C1P(C1=CC=C(C)C=C1)C1=CC=C(C)C=C1Description: Empagliflozin Irinotecan hydrochloride trihydrate PMID:25804060

α-Cyclodextrin hydrate, 98+%

Product Name : α-Cyclodextrin hydrate, 98+%Synonym: IUPAC Name : 5,10,15,20,25,30-hexakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29-dodecaoxaheptacyclodotetracontane-31,32,33,34,35,36,37,38,39,40,41,42-dodecolCAS NO.Avelumab :51211-51-9Molecular Weight : Molecular formula: C36H60O30Smiles: OCC1OC2OC3C(CO)OC(OC4C(CO)OC(OC5C(CO)OC(OC6C(CO)OC(OC7C(CO)OC(OC1C(O)C2O)C(O)C7O)C(O)C6O)C(O)C5O)C(O)C4O)C(O)C3ODescription: Arbekacin PMID:23539298

N,N,N’,N’-Tetramethyl-p-phenylenediamine dihydrochloride, 98+%

Product Name : N,N,N',N'-Tetramethyl-p-phenylenediamine dihydrochloride, 98+%Synonym: IUPAC Name : dihydrogen N1,N1,N4,N4-tetramethylbenzene-1,4-diamine dichlorideCAS NO.:637-01-4Molecular Weight : Molecular formula: C10H18Cl2N2Smiles: .Pepinemab .Dispase .PMID:24059181 .CN(C)C1=CC=C(C=C1)N(C)CDescription: N,N,N',N'-tetramethyl-p-phenylenediamine dihydrochloride (TMPD) is an oxidizable compound that…

G472311_T01 GRMZM2G058305_T01 GRMZM2G025387_T01 GRMZM5G856738_T

G472311_T01 GRMZM2G058305_T01 GRMZM2G025387_T01 GRMZM5G856738_T02 GRMZM2G112057_T01 GRMZM2G154489_T01 ZMU28376 d GRMZM2G168706_T01 GRMZM2G030673_T01 GRMZM2G088361_T01 GRMZM2G311220_T01 GRMZM2G332660_T01 AC2100134_FGT014 GRMZM2G104125_T01 AC2338711_FGT003 GRMZM2G028086_T01 GRMZM2G099425_T01 GRMZM2G365035_T01 GRMZM2G157068_T01 GRMZM2G053868_TGenBank accession numbers; - represents no alternative splice variants.Kong et…

By(a)displacinghistonedeacetylasefromthepRBcomplex;(b)acetylationandliberationofE2F1;and(c)drivingpituitarycellsintoSphase(61).HMGA2alsoinducespituitarytumor

By(a)displacinghistonedeacetylasefromthepRBcomplex;(b)acetylationandliberationofE2F1;and(c)drivingpituitarycellsintoSphase(61).HMGA2alsoinducespituitarytumor cyclinB2(CCNB2)anddirectlyinducesCCNB2promotertranscriptionalactivity.GH-secretingtumorscoexpresshighlevelsof CCNB2,HMGA1,andHMGA2(61,62). PTTG.Pituitarytumor ransformingprotein(PTTG),isolated frompituitarytumorcells,facilitatesthespindlecheckpointby actingasasecurintoinhibitseparaseandenablefaithfulsister chromatidseparation(63,64).Pttgmediatesinvitrotransformationandinvivotumorigenesisinmice,andPTTGoverexpression inducesaneuploidywithdysregulatedG2/Mcheckpointsurveillance,resultinginabnormalmitosisandchromosomalinstability (65).PTTGmodulatesp53,participatinginDNAdamage/repairandapoptosis(668).PTTGisabundantlyexpressedinpituitary adenomas(69)andcorrelateswithtumorinvasivenessandrecurrence;itisinducedearlyinestrogen-inducedpituitarytumorigenesis.PTTGelicitspituitarytumorigenesisinatransgenicmodelof pituitary-directedPttgoverexpression,resultinginfocalpituitary hyperplasiaandfunctionaladenomaformation(70). Pituitary senescence.Pituitarycarcinomasareexceedinglyrare,and onlyisolatedcasesofpituitarymetastasesderivedfromGH-secretingadenomashavebeenreported.GH-secretingadenomasthus representanintriguingmodelforstudyingtriggersofmalignant transformation.Cellularsenescencemediatedbyoncogenicpathwaysisassociatedwiththeactivationofinhibitorsofcell-cycle progression(suchasp53-mediatedp21),whichprotectthecell fromproproliferativesignalsandactasabufferagainstmalignanttransformation(71).Prematuresenescencemayaccount fortheoverwhelmingpredominanceofbenignversusmalignant GH-secretingpituitarytumors,asmorethan70 ofGH-secreting tumorsoverexpressPTTG,leadingtoaneuploidyandinduction ofsenescencemarkersincludingp21andsenescence-associated -galactosidase(72).Incontrast,p21isweaklyexpressedinnormal pituitarytissueandundetectableinpituitarycarcinomas.SenescentfeaturesofGH-secretingpituitaryadenomaslikelyconstrain malignanttransformationoftheseinvariablybenignadenomas. Slowreplicativepituitarycell-cycleprogressionisdistinctfromthe rapidcellcycleofskinordigestivetractregenerativetissues(56),…

Hibitor66.6 151.9 sirtuininhibitor101.8 Male Min/OPN(+/-) 29 5.0 sirtuininhibitor3.7 22.eight sirtuininhibitor16.9 72.7 sirtuininhibitor37.six one hundred.5 sirtuininhibitor53.four

Hibitor66.6 151.9 sirtuininhibitor101.8 Male Min/OPN(+/-) 29 5.0 sirtuininhibitor3.7 22.eight sirtuininhibitor16.9 72.7 sirtuininhibitor37.six one hundred.5 sirtuininhibitor53.four MinHibitor66.6 151.9 sirtuininhibitor101.eight Male Min/OPN(+/-) 29 5.0 sirtuininhibitor3.7 22.eight sirtuininhibitor16.9 72.7 sirtuininhibitor37.6 100.5 sirtuininhibitor53.4 Min/OPN(+/+)…